This study produced within the context of the EC-funded projects, FORTESIE and RENOVERTY, provided key data-driven insights and qualifications from the application of the DREEM model in real-life pilots. The presentation focused on the analysis of the cost-effectiveness of diverse portfolios of measures, emphasizing economic viability, energy savings, and sustainability, with the aim to contribute to the development of integrated renovation packages in real-life pilot cases across different European countries.